Closed-Loop Brain Stimulation
via the Phase-Locking Technique
HIGHLIGHTED FEATURE
Real-Time Phase-Locked Stimulation with the Phase-Locking AddIn for EventIDE
Synchronize external stimuli—like auditory tones, visual flashes, or TMS pulses — with the exact phase of ongoing EEG, MEG, EMG, or physiological rhythms using our Phase-Locking AddIn for EventIDE. This advanced solution enables real-time, closed-loop stimulation aligned with user-defined oscillatory phases, opening new doors in memory, attention, sleep, and neuropsychiatric research.
Explore software-only or full hardware-integrated setups. Licensing options are flexible for academic labs and clinical research centers.
WHAT IS THE PHASE-LOCKING ADDIN?
The Phase-Locking AddIn is a specialized plugin for EventIDE software that enables real-time delivery of stimuli locked to precise phases of biological rhythms (e.g., alpha, theta, delta). Unlike retrospective analysis tools, this AddIn works live—predicting upcoming oscillation phases and synchronizing stimuli within 1 ms cycles.
Presenting stimulus (green line) locked to the 45° phase angle of the alpha rhythm.
REAL-TIME CONTROL PANEL
Real-time control panel inside EventIDE for monitoring phase targets and locking success.
KEY FEATURES
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Real-Time Phase Locking to any phase angle of ongoing bio oscillations
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Script-Controlled Dynamic Targeting during experiment runtime
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Multi-Band & Multi-Channel Tracking (e.g., alpha in parietal, theta in frontal)
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Compatible with TMS, auditory, visual, and sensory stimulation systems
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Built for Experimental Science applications
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Synchronized Recording with EEG, ECG, NIRs, and more via EventIDE
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Interactive Locking Visualization and accuracy analysis with PhInsight
HOW IT WORKS
Your EEG signal is streamed live into EventIDE, where the Phase-Prediction AddIn analyzes it in real time using ultra-fast algorithms. As each oscillation approaches its defined phase angle, the system prepares and dispatches a stimulus signal — ensuring the precise temporal alignment needed for effective phase-based stimulation.
Live visualizations, full signal access, and customizable algorithms allow fine-grained control, data recording, and adaptive neurofeedback workflows.
PHINSIGHT INTERFACE
Validate locking accuracy, waveform quality, and phase consistency using PhInsight.
VERIFY, VISUALIZE, AND REFINE WITH PHINSIGHT
PhInsight tool allows post-experiment validation of the locking algorithm:
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Inspect raw vs. filtered signals at locking points
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Review ERP plots aligned to locked phases
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Confirm consistency of oscillations across trials
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Simulate how changes in algorithm parameters (thresholds, target phase definitions, etc.) affect locking precision, error distribution, and event frequency.
Whether you're validating EEG-based triggers or exploring phase-locking to respiratory rhythms, PhInsight bridges real-time control with statistical precision.
Video Demo: Phase-Locked Stimulus Presentation with EventIDE
This short video shows how to set up a fully functional phase-locked stimulus presentation in under 5 minutes using EventIDE. The demonstration uses alpha-band EEG (8–12 Hz) to trigger visual stimuli at specific phases of the brain’s ongoing rhythm—highlighting real-time prediction, precision timing, and visual feedback.
CHOOSE YOUR SETUP
We offer two flexible options depending on your lab’s infrastructure and research goals:
Software-Only Package
Available directly from us
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EventIDE: A powerful experimental design platform with real-time control capabilities.
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Phase-Prediction AddIn: Predicts upcoming oscillatory phases and times stimuli accordingly.
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PhInsight Tool: For post-hoc verification and fine-tuning of locking parameters.
Use this configuration with your existing EEG amplifier and stimulation hardware.
See full list of supported hardware here.
Integrated Hardware-Software System
Offered by our trusted partner PsyPhy
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EventIDE Core + Phase‑Prediction AddIn: Full-featured neurobehavioral experiment software for real-time phase‑locked stimulation.
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PsyPhy Measurement Suite: Advanced amplifier hardware capable of recording EEG (electroencephalography), ERP (event-related potentials), ECG (heart activity), EOG (eye movements), EMG (muscle activity), and GSR (skin conductance) with up to 19 unipolar channels and 4 bipolar channels — all synchronized and available at up to 1 kHz sampling.
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Turnkey Integration: Includes real‑time synchronization, multimodal recording, stimulus triggering, and visualization — verified for laboratory-grade precision.
Complete EEG-Based Experiment Setup with PsyPhy & EventIDE
This video demonstrates a full experimental setup using PsyPhy’s EEG amplifier and EventIDE software. It showcases how the tightly integrated system enables precise, phase-locked visual stimulation based on alpha-band EEG, highlighting both the hardware capabilities and real-time control workflow in action.
RESEARCH APPLICATIONS
Sleep Neuroscience
Neurostimulation Optimization
Memory & Cognition
Depression & Mood Disorders
Attention & Sensory Processing
ADHD & Developmental Research
Licensing & Purchase Options
The Phase-Locking AddIn is available through flexible licensing options ranging from 1 month to 5 years, allowing researchers to choose the duration that best fits their project timeline and budget. Licenses are offered exclusively for non-commercial, academic, and non-profit research.
Product | License | Duration | Price* |
|---|---|---|---|
EventIDE | Per computer | 1 month - 5 years | € 70,00 - € 3.066,00 |
Phase-Locking AddIn | Add-on | 1 month - 5 years | € 70,00 - € 2.500,00 |
PhInsight | Add-on | 1 month - 5 years | € 29,00 - € 1.000,00 |
Hardware+Software Setup | via PsyPhy | Custom | On request |
*Prices exclude VAT.